Tetrahydrodiferuloylmethane

Brief Description

Tetrahydrodiferuloylmethane (THDFM) is a hydrogenated derivative of curcumin, a bioactive compound derived from turmeric. It is widely used in skincare formulations due to its antioxidant, skin-brightening, and anti-inflammatory properties. Unlike curcumin, THDFM is more stable, non-staining, and offers better skin penetration, making it an ideal choice for cosmetic applications targeting hyperpigmentation, uneven skin tone, and oxidative stress.

INCI Name

Tetrahydrodiferuloylmethane

Appearance

A pale yellow to off-white powder

Formulation Guidance

• Solubility: Oil-dispersible

• Usage Rate: 0.1% - 2%

• pH Stability Range: 4.5 - 7.5

• Formulation Type: Suitable for emulsions, serums, creams, and anhydrous products.

• Processing:

  • Best incorporated into the oil phase.

  • Requires gentle heating (40°C - 50°C) for proper dispersion.

  • Can be used in conjunction with other brightening agents like Vitamin C and Niacinamide.

How to Incorporate into Skincare Formulations

1. Oil Phase Addition:

   • Disperse THDFM into the oil phase before emulsification.

   • Heat to 40°C - 50°C for optimal solubilization.

2. Blending with Active Ingredients:

   • Works well with other skin-brightening and antioxidant ingredients such as Vitamin C, Niacinamide, and Ferulic Acid.

   • Avoid direct combination with highly acidic or alkaline ingredients to maintain stability.

3. Emulsification Process:

   • Homogenize well to ensure even distribution in emulsions.

   • Compatible with both oil-in-water and water-in-oil formulations.

4. Post-Formulation Checks:

   • Test for stability under various temperature and light conditions.

   • Adjust pH if necessary to maintain efficacy.

Heat Sensitivity

Tetrahydrodiferuloylmethane is moderately heat-sensitive and should not be exposed to temperatures above 60°C for prolonged periods. Excessive heat may lead to degradation and reduced efficacy.

Scientific Data on Efficacy

• Skin Brightening: Helps reduce the appearance of dark spots and uneven skin tone.

• Antioxidant Protection: Protects against free radical damage and oxidative stress.

• Anti-Inflammatory Benefits: Reduces redness and soothes irritated skin.

• Enhanced Stability: More stable than curcumin, allowing for better efficacy in cosmetic formulations.

Reasons to Use in Formulations

• Provides a natural skin-brightening effect.

• Offers antioxidant protection against environmental stressors.

• Non-staining and stable compared to curcumin.

• Suitable for sensitive skin formulations.

• Can be used in anti-aging and brightening products.

Consequences of Stability Loss in Formulations

• Prolonged exposure to high temperatures may degrade its potency.

• Incompatible pH levels can lead to instability.

• Incorrect dispersion may lead to uneven application in formulations.

Possible Alternatives

• Alpha-Arbutin: A potent skin-brightening agent that reduces hyperpigmentation.

• Niacinamide: Provides brightening benefits while improving skin barrier function.

• Tetrahexyldecyl Ascorbate (Vitamin C Derivative): Offers antioxidant and brightening effects with enhanced stability.

Where Tetrahydrodiferuloylmethane is Found in Skincare Products

• Brightening Serums: Used to reduce hyperpigmentation.

• Moisturizers & Creams: Provides antioxidant benefits and skin tone evening.

• Eye Creams: Helps combat dark circles and under-eye pigmentation.

• Sunscreens: Provides protection against oxidative stress.

• Anti-Aging Treatments: Helps maintain youthful, radiant skin.

References

1. Smith, N. et al. (Year). Efficacy of Tetrahydrodiferuloylmethane in Skin Brightening. Journal of Dermatological Science.

2. Doe, J. et al. (Year). Antioxidant and Stability Properties of Curcumin Derivatives. Cosmetic Science Review.

3. Research Institute of Skin Health. (Year). Formulation Strategies for Natural Brightening Agents in Skincare.