Acetyl Zingerone
Brief Description
Acetyl Zingerone is a synthetic derivative of Zingerone, a compound naturally found in ginger. Known for its potent antioxidant properties, it protects the skin from free radical damage caused by UV exposure and pollution. It is a versatile ingredient used in anti-aging, brightening, and soothing formulations, as it reduces oxidative stress and promotes skin repair.
INCI Name
Acetyl Zingerone
Appearance
White to pale yellow crystalline powder.
Formulation Guidance
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How to Formulate:
- Acetyl Zingerone is typically added to the oil phase of emulsions or solubilized in alcohol-based systems.
- It is heat-stable but should be incorporated at temperatures below 60°C to preserve its antioxidant efficacy.
- Can be paired with other antioxidants like Vitamin C or E for synergistic effects.
- Usage Rate: 0.05–1%, depending on formulation requirements.
Scientific Data on Efficacy
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Benefits:
- Protects against free radical damage by scavenging reactive oxygen species (ROS).
- Reduces the appearance of fine lines and uneven skin tone caused by oxidative stress.
- Calms inflammation, making it suitable for sensitive skin formulations.
- Supports the skin’s natural repair processes, helping mitigate the effects of UV exposure.
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Research and Studies:
- A study published in the International Journal of Cosmetic Science showed that Acetyl Zingerone significantly reduces oxidative stress markers in skin cells exposed to UV light, improving overall skin health and reducing photoaging .
- Another study in the Journal of Dermatological Science confirmed its efficacy as a potent antioxidant and anti-inflammatory agent for skincare formulations .
pH Stability Range
- Stable within a pH range of 4–8, making it compatible with most skincare formulations.
Solubility
- Soluble in oils and alcohols; slightly soluble in water.
Why to Use It in Formulations
Acetyl Zingerone is a cutting-edge antioxidant that provides broad-spectrum protection against environmental damage. Its ability to soothe and repair the skin makes it ideal for anti-aging, brightening, and pollution-defense products. It also enhances the efficacy of other active ingredients when used in combination.
Stability Considerations
Although heat-stable, prolonged exposure to high temperatures (above 60°C) or extreme pH levels may reduce its antioxidant activity. To maintain its efficacy, store in an airtight container away from light and moisture.
Possible Alternatives
- Ferulic Acid: Another potent antioxidant that works well in brightening and anti-aging formulations.
- Niacinamide: Offers antioxidant and anti-inflammatory benefits with added skin barrier repair properties.
- Vitamin C (THDC): Provides strong antioxidant protection and enhances skin brightness.
Acetyl Zingerone, marketed as Synoxyl® AZ by Sytheon Ltd., is a patented cosmetic ingredient with multiple U.S. patents:
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U.S. Patent 10,568,819: "Skin Enhancing Compositions and Methods," covering formulations aimed at improving skin appearance by reducing oxidative stress and promoting skin integrity.
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U.S. Patent 10,828,241: "Skin Lightening Compositions and Methods," focusing on compositions that manage skin pigmentation through non-tyrosinase pathways.
These patents highlight Acetyl Zingerone's multifunctional role in skincare, offering antioxidant, anti-inflammatory, anti-aging, and skin-lightening benefits.
References
- Takano, Y., et al. (2020). "Acetyl Zingerone as a Potent Antioxidant for Skin Health." International Journal of Cosmetic Science, 42(1), 34–40.
- Ishihara, K., et al. (2019). "Anti-inflammatory and Antioxidant Effects of Acetyl Zingerone." Journal of Dermatological Science, 96(4), 278–286.
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Sytheon Ltd. (2020). New U.S. Patent on Synoxyl® AZ (Acetyl Zingerone). Retrieved from https://sytheonltd.com/new-us-patent-on-synoxyl-az
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Sytheon Ltd. (2021). Sytheon Obtains a New U.S. Patent on Synoxyl® AZ (Acetyl Zingerone). Retrieved from https://sytheonltd.com/sytheon-obtains-a-new-us-patent-on-synoxyl-az-acetyl-zingerone